The concentrations of other cytokines, such as tumour necrosis factor and IL-2, were unchanged. IL-6 was significantly increased in plasma ( P=0.04) and CSF ( P=0.04) in stroke dogs compared with healthy controls. Interleukin (IL)-2, IL-6, IL-8, IL-10 and tumour necrosis factor in the plasma, CSF and brain homogenates were measured using a canine-specific multiplex immunoassay.
Blood and CSF were collected from dogs less than 72 h after a spontaneous ischaemic stroke. The aims of this study were to investigate cytokine concentrations in plasma and cerebrospinal fluid (CSF) in dogs with acute ischaemic stroke and to search for correlations between infarct volume and cytokine concentrations. Community-dwelling domestic dogs suffer from spontaneous ischaemic stroke, and therefore, offer the opportunity to study the cytokine response in a noninvasive set-up. Cytokine studies in animal models of surgically induced stroke may, however, be influenced by the fact that the surgical intervention itself contributes towards the cytokine response. Inflammatory cytokines are potential modulators of infarct progression in acute ischaemic stroke, and are therefore possible targets for future treatment strategies. The work cannot be changed in any way or used commercially without permission from the journal. This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. IDepartment of Pharmacology, University of Oxford, Oxford, UKĬorrespondence to Hanne Gredal, DVM, PhD, Department of Veterinary Clinical and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, DyrlægeFrederiksberg, Denmark Tel: +45 2128 8680 fax: +45 3533 2929 e-mail: ADepartment of Veterinary Clinical and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, FrederiksbergīCentre of Functionally Integrative Neuroscience, Aarhus University, AarhusĬDepartment of Neurobiology Research, Institute of Molecular MedicineĭBRIDGE (Brain Research – Inter-Disciplinary Guided Excellence), Department of Clinical Research, University of Southern DenmarkĮDepartment of Neurology, Odense University Hospital, Odense, DenmarkįExperimental Neuroinflammation Laboratory, Department of Experimental Medical Science, BMC, Lund University, Lund, Sweden
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